This is an inherited disorder characterized by normal blood pressure, hypomagnesemia, hypokalemia, elevated plasma renin, increased prostaglandin secretion and increased aldosterone. Increased renin secretion results from hyperplasia of the granular cells of the juxtaglomerular apparatus. The disease usually manifests during childhood and affected children often exhibit stunted growth. The underlying pathology is believed to be a defect in sodium chloride resorption in the loop of Henle and/or a distal nephron lesion that causes increased potassium secretion.