DIFFERENTIAL DIAGNOSIS OF HEMATURIA

NON-RENAL CAUSES

Hematologic

     Sickle Cell Disease 

     Thrombocytopenia

Bleeding diathesis

     Hemophilia

     von Willebrand Disease

Medications

     Cyclophosphamide

     Coumadin

     Heparin

Genitourinary Tract Disease (Postrenal)

     Benign Prostatic Hypertrophy

     Calculi (ureter, bladder, or urethra)

     Infections (cystitis, prostatitis, epididymitis, urethritis)

     Neoplasms (renal pelvis, bladder, ureter, urethra, prostate)

RENAL CAUSES

     Glomerular Disease (associated with dysmorphic RBCs, RBC casts or heavy proteinuria)

     Diseases Associated with Low Complement Levels

          Membranoproliferative Glomerulonephritis

          Poststreptococcal Glomerulonephritis

          Systemic Lupus Erythematosus

          Cryoglobulinemia

          Infective Endocarditis

          Hepatitis C

          Ventriculoatrial Shunt Infection

     Diseases Associated with Normal Complement Levels

          Primary Renal Diseases

          IgA nephropathy (Bergers Disease)

          Idiopathic Rapidly Progressive Glomerulonephritis

Systemic Disease

     Goodpasture's Syndrome

     Hemolytic uremic Syndrome

     Henoch-Schonlein Purpura

     Thrombotic Thrombocytopenic Purpura

     Vasculitis

          Wegener's Granulomatosis

          Polyarteritis Nodosa

          Hypersensitivity Vasculitis

          Microscopic Polyangiitis 

     Alport Syndrome

     Malignant Hypertension

     Loin Pain Syndrome

Tubulointerstitial (Nonglomerular) Disease

Trauma

Hypercalciuria

Hyperuricosuria

Papillary Necrosis

Infection

     Pyelonephritis

          Bacterial

          Tuberculosis

Interstitial Nephritis

Cystic Kidney Disease

     Polycystic Kidney

     Medullary Sponge Kidney

Neoplasia

     Benign Tumors

          Oncocytomas

          Angiomyolipomas

          Leiomyomas

          Fibromas

          Lipomas

     Malignant Tumors

          Renal Cell Carcinoma

          Sarcoma

          Lymphoma

          Nephroblastoma

          Urothelial Tumors

          Metastatic Lesions

Vascular Disease

     Renal Infarction

     Renal Vein Thrombosis

     AVM

Hereditary Hemorrhagic Telangiectasia (Rendu-Osler-Weber Disease)