DIFFERENTIAL DIAGNOSIS OF HEMOLYSIS

Intravascular

     Microangiopathic Hemolytic Anemias

     Turbulent Flow

     Malignant Tumors

     Malignant Hypertension

     Severe Aortic Stenosis

     Prosthetic Cardiac Valves

     Disseminated Intravascular Coagulation (DIC)

     Thrombotic Thrombocytopenic Purpura (TTP)

     March Hemoglobinuria

     Immune Hemolytic Anemias

          Hemolytic Transfusion Reaction

          Donath-Landsteiner Antibody

     Infections

          Malaria

         Clostridium perfringens

          Bartonella bacilliformis

     Enzyme Deficiencies

          Glucose-6-Phosphate Dehydrogenase Deficiency

          Glutathione Reductase Deficiency

     Paroxysmal Nocturnal Hemoglobinuria

Extravascular

     Hypersplenism

     Congenital Red Cell Membrane Defects

          Hereditary Spherocytosis

          Hereditary Elliptocytosis

          Hereditary Stomatocytosis

     Hypophosphatemia

     Pyruvate Kinase Deficiency

     Wilson's Disease

     Hemolytic Uremic Syndrome (HUS)

     Autoimmune Hemolysis

     Sickle Cell Disease

     Spur Cell Anemia

     Thalassemia