URIC ACID 3 - 7.5 HIGH DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS FOR HYPERURICEMIA

Uric Acid Overproduction

     Primary Hyperuricemia

          Idiopathic

          Enzymatic Abnormalities

               HGPRT Deficiency

                    Lesch-Nyhan Syndrome 

               PRPP Synthetase Superactivity

     Secondary Hyperuricemia

          Excessive Dietary Purine Intake

          Increased Nucleotide Turnover

          Myeloproliferative Disorders

          Lymphoproliferative Disorders

          Essential Thrombocytosis 

          Hemolytic Diseases

          Accelerated ATP Degradation

          Glycogen Storage Diseases ( types I, III, V, VII )

          Fructose Ingestion, Hereditary Fructose Intolerance

          Ethanol Abuse

          Tumor Lysis Syndrome 

          Hypoxemia

Uric Acid Underexcretion

     Primary Hyperuricemia

          Idiopathic         

     Secondary Hyperuricemia

          Renal Failure

               Acute

               Chronic

          Rhabdomyolysis

         Multiple Myeloma 

          Lactic Acidosis

          Diabetes Insipidus 

          Dehydration

          Hyperparathyroidism

          Medications

               Diuretics

               Cyclosporine

               Pyrazinamide

               Ethambutol