WBC 4.0 - 10.9 HIGH DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS OF LEUKOCYTOSIS

 

NEUTROPHILIA

     Infections

     Leukemoid Reaction

     Inflammatory Disorders

     Malignancies

     Tissue Destruction

     Pancreatitis

     Hemolysis

     Diabetic Ketoacidosis

     Hemorrhage

     Myeloproliferative Disorders

          Polycythemia Vera (PCV)

          Chronic Myelogenous Leukemia (CML)

          Myelofibrosis with Myeloid Metaplasia

     Exercise Induced

     Pregnancy

     Stress Induced

     Cigarette Associated

     Idiopathic

     Medications

          Steroids

          GCSF Therapy

          GM-CSF Therapy 

 

LYMPHOCYTOSIS

     Infection

          Viral

               HIV

               EBV Infectious Mononucleosis

               CMV 

              Viral Hepatitis

         Tuberculosis

           Rickettsia

           Brucellosis

           Toxoplasmosis

           Babesiosis

           Syphilis

           Pertussis

    Asplenia/Postsplenectomy 

     Chronic Lymphocytic Leukemia

     Sezary Syndrome

     Large Granular Lymphocyte Leukemia

     T-Cell Non-Hodgkin Lymphoma

     HTLV-1+ T-Cell Leukemia/Lymphoma

     Mantle Cell Lymphoma

     Follicular Non-Hodgkin Lymphoma

     Hairy Cell Leukemia

     Splenic Marginal Zone Lymphoma

     Lymphoplasmacytoid Lymphoma

     B-Cell Prolymphocytic Leukemia

     T-Cell Prolymphocytic Leukemia 

     Thyrotoxicosis

     Addisons Disease

     Thymoma

     Drug Induced

 

EOSINOPHILIA

     Hypereosinophilic Syndrome

     Idiopathic Eosinophilia 

     Malignancies

          Hodgkin's Disease

          Non-Hodgkin's Disease

          Leukemia

               Chronic Myelomonocytic Leukemia

               Chronic Eosinophilic Leukemia-Not Otherwise Specified (CEL-NOS)

          Clonal Eosinophilia

               PDGFRA

               PDGFRB

               FGFR1 

          Systemic Mastocytosis 

     Asthma

     Allergic Reactions

     Acute Interstitial Nephritis

     Addisons Disease

     Parasitic Infections

          Ancylostoma duodenale (hookworm)

          Ascaris lumbricoides

          Filariasis

          Trichuris trichiura

          Anisakis

          Heterophyes

          Capillaria philippinensis

          Clonorchis sinensis

          Opisthorchis 

          Necator americanus (hookworm)

          Schistosoma haematobium

          Schistosoma japonicum

          Schistosoma mansoni 

          Strongyloides stercoralis

          Fasciola hepatica

          Fasciola gigantica 

          Paragonimus westermani

          Brugia malayi

          Wuchereria bancrofti

          Angiostrongylus

          Gnathostoma

          Loa loa

          Onchocerca volvuous

          Isospora belli

          Dientamoeba fragilis

          Toxocara canis

          Toxocara cati

          Trichinella spiralis

         Scabies sarcoptes scabiei hominis (scabies infestation) 

     Pulmonary Eosinophilic Syndromes

          Acute Eosinophilic Pneumonia

          Chronic Eosinophilic Pneumonia

           Loeffler's Syndrome 

          Allergic Bronchopulmonary Aspergillosis 

     Connective Tissue Disease    

          Chug-Strauss Syndrome

          Eosinophilic Fasciitis

          Rheumatoid Arthritis

          Systemic Lupus Erythematosus

          Scleroderma

Other

     Cholesterol Emboli

     Coccidioidomycosis 

     Allergic Bronchopulmonary Aspergillosis (ABPA)

     Dermatologic Conditions

          Bullous Pemphigoid

          Dermatitis Herpetiformis

BASOPHILIA

     Myeloproliferative Disorders

          Polycythemia Vera (PCV)

          Chronic Myelogenous Leukemia (CML)

     Myelofibrosis