WBC 4.0 - 10.9 LOW DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS OF LEUKOPENIA

NEUTROPENIA

     Pseudoneutropenia 

     Kostmann Syndrome (Congenital Agranulocytosis)

     Fanconi's Anemia 

     Cyclic Neutropenia 

     Aplastic Anemia

     Pure Red Blood Cell Aplasia

     Parvovirus B19 

     Paroxysmal Nocturnal Hemoglobinuria 

     Marrow Infiltration

          Infectious

               Bacterial

               Fungal

               Parasitic

          Malignant

               Metastatic Disease

               Large Granular Lymphocyte Leukemia

               Myelodysplastic Syndromes 

                     Refractory Anemia

                         Refractory Anemia with Ringed Sideroblasts

                         Refractory Anemia without Ringed Sideroblasts 

                    Refractory Cytopenia and Multilineage Dysplasia

                    Refractory Anemia with Excess of Type 1 Myeloblasts

                    Refractory Anemia with Excess of Type 2 Myeloblasts

                    Myelodysplastic Syndrome with Isolated deletion of 5q

                    Unclassified Myelodysplastic Syndrome  

     Acute Agranulocytosis

     Copper Deficiency

          Dietary Deficiency

          Post Gastrectomy

          Zinc Toxicity 

     Drug Induced

          Imipramine

          Penicillamine

         NSAIDs 

          Antithyroid Agents

               Methimazole

               Propylthiouracil 

          Antibiotics

               Penicillins

               Cephalosporins

               Sulfonamides

               Chloramphenicol

               Vancomycin

               Trimethoprim-Sulfamethoxazole

               Rifampin 

          Chemotherapeutic Agents

          Quinidine

          Procainamide

          Diuretics

          Methotrexate

          Hydroxyurea

          Interferon 

          Pyrimethamine

          Gold Salts

          Hydroxychloroquine 

          Diphenylhydantoin

          Carbamazepine

           Valproic Acid

     HIV Infection

     Folate Deficiency

     Vitamin B12 Deficiency (Pernicious Anemia)

     Sepsis

     Redistribution

          Hypersplenism

          Margination 

     Felty Syndrome

     Systemic Lupus Erythematosus 

     Idiopathic Immune Neutropenia 

LYMPHOPENIA

     Congenital Immunologic Deficiency Syndromes

          Swiss-type Agammaglobulinemia

          Thymic Alymphoplasia

          DiGeorge Syndrome

          Wiskott-Aldrich Syndrome

          Bruton-type Agammaglobulinemia

    Common Variable Immunodeficiency Syndrome 

     Thymoma

     Aplastic Anemia

     Sarcoidosis

     Renal Failure

     Systemic Lupus Erythematosus

     Leukemia

     Viral Infections

           HIV

           Severe Acute Respiratory Syndrome

     Sepsis

     Systemic Lupus Erythematosus

    Rheumatoid Arthritis

     Alcoholism 

     Multiple Myeloma

     Hodgkins Disease

     Cushings Syndrome

     Stress

     Corticosteroid Administration

     Alkylating Agents

     Radiation