PLT 150 - 370 LOW DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS OF THROMBOCYTOPENIA

Decreased Marrow Production

     Viral

          Rubella Virus

          Cytomegalovirus

          Epstein-Barr Virus

          Human Immunodeficiency Virus (HIV)

          Parvovirus B19 

     Toxin Induced

          Ethanol

          Cocaine

     Drug Hypersensitivity

          Heparin

                Heparin-Induced Thrombocytopenia 

          Thiazide Diuretics

          Estrogens

          Chemotherapeutic Agents

          Interferon

     Myelodysplastic Syndromes 

           Refractory Anemia

               Refractory Anemia with Ringed Sideroblasts

               Refractory Anemia without Ringed Sideroblasts 

          Refractory Cytopenias and Multilineage Dysplasia

          Refractory Anemia with Excess of Type 1 Myeloblasts

          Refractory Anemia with Excess of Type 2 Myeloblasts

          Myelodysplastic Syndrome with Isolated deletion of 5q

          Unclassified Myelodysplastic Syndrome

     Chronic Lymphocytic Leukemia 

     Generalized Bone Marrow Disease

          Malignancy

          Pure Red Blood Cell Aplasia 

          Systemic Infections

               Ehrlichiosis

               Brucellosis

               Rocky Mountain Spotted Fever

          Aplastic Anemia

          Myelofibrosis

          Megaloblastic Hematopoiesis

               B12 Deficiency

               Folate Deficiency

     Hereditary Causes with Large Platelets (Macrothrombocytopenia)

          Bernard-Soulier Disease

          TAR Syndrome

          May-Hegglin Anomaly

          Fechtner Platelet Syndrome

          Sebastian Platelet Syndrome

           Epstein Syndrome

          Eckstein Syndrome

          Gray Platelet Syndrome

          Montreal Platelet Syndrome

          Enyeart Anomaly  

          Giant Platelets with Velocardiofacial Syndrome

          Giant Platelets with Abnormal Membrane Glycoproteins and Mitral Valve Insufficiency

          Familial Macrothrombocytopenia with Glycoprotein IV Abnormality

          Mediterranean Macrothrombocytopenia 

     Hereditary Causes without Large Platelets

          Type 2B von Willebrand Disease

          Platelet Type von Willebrand Disease  (Pseudo von Willebrand Disease)

          Wiskott-Aldrich (Campbell) Syndrome

          Thrombocytopenia Absent Radius Syndrome 

          Diamond-Blackfan Syndrome

Increased Peripheral Platelet Destruction

     Selective Thrombocytopenia

     Autoimmune

          Acute Idiopathic Thrombocytopenic Purpura

          Chronic Idiopathic Thrombocytopenia Purpura

          Alloimmune

          Posttransfusion

     Other

          Thrombotic Thrombocytopenic Purpura (TTP)

          Hemolytic Uremic Syndrome (HUS)

          Disseminated Intravascular Coagulation (DIC)

          Systemic Lupus Erythematosus (SLE)

          Antiphospholipid Syndrome (APS)

          Paroxysmal Nocturnal Hemoglobinuria (PNH) 

          Alport Syndrome 

Sequestration

     Hypersplenism

     Hypothermia