GUIDELINES FOR THE TREATMENT OF SYPHILIS

STAGE OF INFECTION PRIMARY TREATMENT THERAPY FOR PCN ALLERGIC
incubating, primary, secondary, or early latent syphilis benzathine PCN 2.4 million units IM for one single dose tetracycline 500mg PO QID x 15 days or

doxycycline 100 mg PO BID x 14 days or

erythromycin 500 mg PO QID x 14 days or

ceftriaxone 125 mg IM QD x 10 days or 250 mg IM QOD x 5 doses or 1000 mg IM x 4 doses

syphilitic infection lasting longer than 1 year to include latent, late benign, and cardiovascular syphilis benzathine PCN 2.4 million units IM each week for 3 weeks tetracycline 500 mg PO QID x 4 weeks or

doxycycline 100 mg PO BID x 4 weeks

neurosyphilis

aqueous crystalline PCN G 2-4 million units IV q 4 hours x 10 days followed by benzathine PCN G 2.4 million units IM each week x 3 weeks

ceftriaxone 1 gm IM/IV QD x 14 days or

tetracycline 500 mg PO QID x 4 weeks

pregnant women

appropriate PCN therapy for the stage of infection as described above

desensitization to PCN followed by appropriate therapy for the stage of infection as described above