HGB 12 - 16.5 LOW DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS FOR ANEMIA

Decreased Production (Low Reticulocyte Index)

Microcytic

     Iron Deficiency Anemia

     Thalassemia

     Sideroblastic Anemia

     Lead Intoxication

     Copper Deficiency

     Zinc Toxicity 

     Chronic Disease 

Normocytic

     Chronic Disease

     Malignancies

     Pure Red Blood Cell Aplasia

    Diamond-Blackfan Anemia

     Fanconi's Anemia 

     Parvovirus B19 

     Addison's Disease

          Waterhouse-Friderichsen Syndrome 

     Hypothyroidism

     Aplastic Anemia

     Chronic Renal Failure

     Myeloid Metaplasia with Myelofibrosis

     Multiple Myeloma

     Ribavirin Therapy 

     Copper Deficiency 

Macrocytic

     Oval Macrocytosis 

          B12 Deficiency Anemia

          Folate Deficiency Anemia

          Myelodysplastic Syndromes

               Refractory Anemia

                    Refractory Anemia with Ringed Sideroblasts

                    Refractory Anemia without Ringed Sideroblasts 

               Refractory Cytopenias and Multilineage Dysplasia

               Refractory Anemia with Excess of Type 1 Myeloblasts

               Refractory Anemia with Excess of Type 2 Myeloblasts

               Myelodysplastic Syndrome with Isolated deletion of 5q

               Unclassified Myelodysplastic Syndrome 

     Round Macrocytosis

          Liver Disease

          Alcoholism

          Chemotherapeutic Agents

          Preleukemia

          Copper Deficiency

              Dietary Deficiency

               Post Gastrectomy

              Malabsorption

               Zinc Toxicity

               Copper Chelator Therapy          

          Medications

Increased Peripheral Destruction or Loss (Elevated or Appropriate Reticulocyte Index)

     Hemorrhage (Normal Indirect Bilirubin and LDH)

     Hemolysis (Elevated Indirect Bilirubin and LDH)

          Intravascular

               Hemolytic Transfusion Reaction

               Malaria

               Snake Bite 

               Glucose-6-Phosphate Dehydrogenase Deficiency

               Paroxysmal Nocturnal Hemoglobinuria

               Hypophosphatemia 

          Extravascular

               Hypersplenism

               Hereditary Spherocytosis

               Pyruvate Kinase Deficiency

               Wilsons Disease

               Disseminated Intravascular Coagulation

               Hemolytic Uremic Syndrome

               Thrombotic Thrombocytopenic Purpura