CA 8.6 - 10.3 LOW DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS OF HYPOCALCEMIA

PTH Absent/Decreased

     Hypoparathyroidism

          Hereditary

               DiGeorge Syndrome

               Genetic Mutation

                    GATA3 Gene

                    PTH Gene

                    GCMb Gene 

          Acquired

          Hypomagnesemia

         Hypocalcemic Hypercalciuria 

PTH Ineffective

     Chronic Renal Failure

     Vitamin D Deficiency

     Hypomagnesemia

     Defective Vitamin D Metabolism

          Anticonvulsant Ingestion (induces acquired vitamin D deficiency by increasing metabolism to inactive compounds )

          Rickets Type I

          Active Vitamin D Resistance

               Rickets Type II

          Pseudohypoparathyroidism

PTH Excess

     Fanconi Syndrome 

     Tumor Lysis Syndrome

     Acute Renal Failure

     Rhabdomyolysis

     Other

          Celiac Disease 

          Hypoalbuminemia

          Pancreatitis

          Alkalosis

          Thalassemia

          Wilson's Disease

          Hemochromatosis

         Theophylline Toxicity