TOTAL PROT. 6.5 - 8.3 HIGH DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS FOR AN ELEVATED TOTAL PROTEIN

POLYCLONAL GAMMOPATHY

    Liver Disease 

          Autoimmune Hepatitis 

          Alcoholic Hepatitis

          Hemachromatosis

          Alpha-1 Antitrypsin Deficiency 

          Primary Biliary Cirrhosis

          Viral Hepatitis

          Cirrhosis

          Primary Sclerosing Cholangitis

     Connective Tissue Disease

          Sjogren Syndrome

          Rheumatoid Arthritis

          Systemic Lupus Erythematosus

          Mixed Connective Tissue Disease

          Eosinophilic Fasciitis

          Ankylosing Spondylitis

          Temporal Arteritis 

          Raynaud Phenomenon

          Familial Mediterranean Fever

          Inclusion Body Myositis

          Scleroderma

          Cryoglobulinemia 

     Hematologic Conditions

          Low-grade Lymphoma

          High-grade T-cell Lymphoma

          Large Granular Lymphocytic Leukemia

          Chronic Myelomonocytic Leukemia

          Chronic Lymphocytic Leukemia

          Hairy Cell Leukemia

          Plasma Cell Leukemia 

          Angioimmunoblastic Lymphadenopathy with Dysproteinemia

          Pseudolymphoma

          Kikuchi Disease

          Castleman Disease

          Histiocytosis X

          Sinus Histiocytosis with Massive Lymphadenopathy

          Intracranial Plasma Cell Granulomata

          Cutaneous Eruptive Histiocytoma

         Chronic Active Epstein Barr Virus Infection Syndrome

          Severe Autoimmune Lymphoproliferative Syndrome 

          Idiopathic Neutropenia

          Idiopathic Thrombocytopenic Purpura

          Hemophilia A

          Thalassemia Major

          Sickle Cell Anemia

          Fanconi Anemia 

     Malignancy

          Hepatocellular Carcinoma

          Ovarian Carcinoma

          Squamous Cell Carcinoma of the Lung

          Pancreatic Adenocarcinoma

          Renal Cell Carcinoma

          Chondrosarcoma

         Gastric Carcinoma 

     Infections

          Viral Hepatitis

          Pyelonephritis

         Renal Abscess 

          Tuberculosis

          Bacterial Endocarditis

          Syphilis

          HIV

          Osteomyelitis

          Bacteremia 

          Brucellosis

          Whipple Disease

          Lyme Disease

          Leishmaniasis

          Chagas Disease

          Toxocara canis Infection 

          Varicella

          Vaccinia

     Neurologic Condition

          Acquired Chronic Dysimmune Demyelinating Polyneuropathy

          HTLV-1-Associated Myelopathy

          Chronic Progressive Sensory Ataxic Neuropathy

          Pure Motor Neuron Disease and Plasma Cell Dyscrasia

          Microangiopathy of Vasa Nervorum in Dysglobulinemic Neuropathy 

     Sarcoidosis

     Inflammatory Bowel Disease 

     Cystic Fibrosis 

     Gaucher Disease

     Meniere Disease

     Cardiac Myxoma

     Asbestos Exposure

     Cryptogenic Organizing pneumonitis

     Lymphoid Interstitial Pneumonia

     Renal Tubular Acidosis 

     Grave's Disease

     Hashimotos's Thyroiditis 

     Autoimmune Pancreatitis

     Syndrome of IgG2 Subclass Deficiency

     Hyperimmunoglobulinemia D and Periodic Fever Syndrome 

MONOCLONAL GAMMOPATHY

     Amyloidosis

     Multiple Myeloma

     Monoclonal Gammopathy of Undetermined Significance (MGUS)

     Smouldering Myeloma 

     POEMS Syndrome 

     Plasmacytoma

     Lymphoid Tumors

     Waldenstroms Macroglobulinemia

     Cryoglobulinemia